"Translocation of Crohn's disease Escherichia coliacross M-cells: contrasting effects of soluble plant fibres and emulsifiers" in Inflammatory Bowel Disease (2010)
" We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation ofEscherichia coli across M-cells. ... Plantain and broccoli NSP markedly reduced E coli translocation across M-cells at 5 mg/ml (range 45.3–82.6% inhibition, p<0.01).... Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml). ... Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli...."
Showing posts with label translocation. Show all posts
Showing posts with label translocation. Show all posts
4.6.11
Does broccoli improve Crohn's symptoms?
"Translocation of Crohn's disease Escherichia coliacross M-cells: contrasting effects of soluble plant fibres and emulsifiers" in Inflammatory Bowel Disease (2010)
" We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation ofEscherichia coli across M-cells. ... Plantain and broccoli NSP markedly reduced E coli translocation across M-cells at 5 mg/ml (range 45.3–82.6% inhibition, p<0.01).... Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml). ... Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli...."
"Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a−/− mice, a model of inflammatory bowel diseases" in Nutrition (2012)
"In comparison to mice fed the control diet, blueberry and broccoli supplementation altered cecum microbiota similarly with the exception of Faecalibacterium prausnitzii, which was found to be significantly lower in broccoli-fed mice. High concentrations of butyric acid and low concentrations of succinic acid were observed in the cecum of broccoli-fed mice. Blueberry- and broccoli-supplemented diets increased colon crypt size and the number of goblet cells per crypt. Only the broccoli-supplemented diet significantly lowered colonic inflammation compared to mice fed the control diet. Translocation of total microbes to mesenteric lymph nodes was lower in broccoli-fed mice compared to blueberry and control diet groups."
" We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation ofEscherichia coli across M-cells. ... Plantain and broccoli NSP markedly reduced E coli translocation across M-cells at 5 mg/ml (range 45.3–82.6% inhibition, p<0.01).... Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml). ... Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli...."
"Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a−/− mice, a model of inflammatory bowel diseases" in Nutrition (2012)
"In comparison to mice fed the control diet, blueberry and broccoli supplementation altered cecum microbiota similarly with the exception of Faecalibacterium prausnitzii, which was found to be significantly lower in broccoli-fed mice. High concentrations of butyric acid and low concentrations of succinic acid were observed in the cecum of broccoli-fed mice. Blueberry- and broccoli-supplemented diets increased colon crypt size and the number of goblet cells per crypt. Only the broccoli-supplemented diet significantly lowered colonic inflammation compared to mice fed the control diet. Translocation of total microbes to mesenteric lymph nodes was lower in broccoli-fed mice compared to blueberry and control diet groups."
Does Polysorbate 80 (emulsifier) worsen Crohn's symptoms?
"Food Components Influence Bacterial Pathology of Crohn's Disease" from Medscape Today News
"The translocation of Escherichia coli across M (microfold) cells and Peyer's patches in Crohn's disease is inhibited by plant fiber but increases with low concentrations of polysorbate 80, an emulsifier commonly used in processed foods, new research findings suggest."
"Translocation of Crohn's disease Escherichia coliacross M-cells: contrasting effects of soluble plant fibres and emulsifiers" in Inflammatory Bowel Disease (2010)
" We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation of Escherichia coli across M-cells. ... Polysorbate-80, 0.01% vol/vol, increased E coli translocation through Caco2-cl1 monolayers 59-fold (p<0.05) and, at higher concentrations, increased translocation across M-cells. Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml) and increased 2-fold by polysorbate-80 (0.1% vol/vol). ...
Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli, but increased by the emulsifier Polysorbate-80. These effects occur at relevant concentrations and may contribute to the impact of dietary factors on Crohn's disease pathogenesis."
"The translocation of Escherichia coli across M (microfold) cells and Peyer's patches in Crohn's disease is inhibited by plant fiber but increases with low concentrations of polysorbate 80, an emulsifier commonly used in processed foods, new research findings suggest."
"Translocation of Crohn's disease Escherichia coliacross M-cells: contrasting effects of soluble plant fibres and emulsifiers" in Inflammatory Bowel Disease (2010)
" We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation of Escherichia coli across M-cells. ... Polysorbate-80, 0.01% vol/vol, increased E coli translocation through Caco2-cl1 monolayers 59-fold (p<0.05) and, at higher concentrations, increased translocation across M-cells. Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml) and increased 2-fold by polysorbate-80 (0.1% vol/vol). ...
Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli, but increased by the emulsifier Polysorbate-80. These effects occur at relevant concentrations and may contribute to the impact of dietary factors on Crohn's disease pathogenesis."
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