4.6.11

Does Polysorbate 80 (emulsifier) worsen Crohn's symptoms?

"Food Components Influence Bacterial Pathology of Crohn's Disease" from Medscape Today News
"The translocation of Escherichia coli across M (microfold) cells and Peyer's patches in Crohn's disease is inhibited by plant fiber but increases with low concentrations of polysorbate 80, an emulsifier commonly used in processed foods, new research findings suggest."

"Translocation of Crohn's disease Escherichia coliacross M-cells: contrasting effects of soluble plant fibres and emulsifiers" in Inflammatory Bowel Disease (2010)
" We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation of Escherichia coli across M-cells. ... Polysorbate-80, 0.01% vol/vol, increased E coli translocation through Caco2-cl1 monolayers 59-fold (p<0.05) and, at higher concentrations, increased translocation across M-cells. Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml) and increased 2-fold by polysorbate-80 (0.1% vol/vol). ...
Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli, but increased by the emulsifier Polysorbate-80. These effects occur at relevant concentrations and may contribute to the impact of dietary factors on Crohn's disease pathogenesis."

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