"Lactocepin Secreted By Lactobacillus Exerts Anti-Inflammatory Effects By Selectively Degrading Proinflammatory Chemokines" in Cell Host and Microbe (2010)
"The intestinal microbiota has been linked to inflammatory bowel diseases (IBD), and oral treatment with specific bacteria can ameliorate IBD. One bacterial mixture, VSL#3, containing Lactobacillus, Bifidobacterium, and Streptococcus, was clinically shown to reduce inflammation in IBD patients and normalize intestinal levels of IP-10, a lymphocyte-recruiting chemokine, in a murine colitis model. We identified Lactobacillus paracasei prtP-encoded lactocepin as a protease that selectively degrades secreted, cell-associated, and tissue-distributed IP-10, resulting in significantly reduced lymphocyte recruitment after intraperitoneal injection in an ileitis model. A human Lactobacillus casei isolate was also found to encode lactocepin and degrade IP-10. L. casei feeding studies in a murine colitis model (T cell transferred Rag2−/− mice) revealed that a prtP-disruption mutant was significantly less potent in reducing IP-10 levels, T cell infiltration and inflammation in cecal tissue compared to the isogenic wild-type strain. Thus, lactocepin-based therapies may be effective treatments for chemokine-mediated diseases like IBD."
Showing posts with label intestinal microbes. Show all posts
Showing posts with label intestinal microbes. Show all posts
4.6.11
"What is the reason behind the increase in the number of patients with IBD in the Asian area occurring after that in the USA and western Europe?"
This important research question is quoted from "Is there a link between food and intestinal microbes and the occurrence of Crohn's disease and ulcerative colitis?" published in JGHF (2008)
Conclusions: The present study supports that intestinal environmental factors, such as food and microbes, are very important for the pathogenesis of IBD. However, further studies are needed, because most studies lack direct evidence of a direct link to the pathogenesis of IBD.
From the Abstract: We found several papers describing the positive association of animal meat and sweets and sugar with the occurrence of CD and UC. An analysis of Japanese epidemiological data suggested that the registered number of patients with CD or UC started to increase more than 20 years after an increased daily consumption of dietary animal meat and fats, and milk and dairy products, and after a decreased consumption of rice. Many studies implied a positive role of intestinal microbes in the occurrence of IBD. Intestinal environmental factors, such as Westernized food and intestinal microbes, seem to be involved in the increased occurrence of IBD. [emphases mine]
Why would the increase in cases be 20 years after? Is it related to the extent of the perfusion of a westernized diet? Or is something else at play?
Conclusions: The present study supports that intestinal environmental factors, such as food and microbes, are very important for the pathogenesis of IBD. However, further studies are needed, because most studies lack direct evidence of a direct link to the pathogenesis of IBD.
From the Abstract: We found several papers describing the positive association of animal meat and sweets and sugar with the occurrence of CD and UC. An analysis of Japanese epidemiological data suggested that the registered number of patients with CD or UC started to increase more than 20 years after an increased daily consumption of dietary animal meat and fats, and milk and dairy products, and after a decreased consumption of rice. Many studies implied a positive role of intestinal microbes in the occurrence of IBD. Intestinal environmental factors, such as Westernized food and intestinal microbes, seem to be involved in the increased occurrence of IBD. [emphases mine]
Why would the increase in cases be 20 years after? Is it related to the extent of the perfusion of a westernized diet? Or is something else at play?
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