Polyamine from Wikipedia
"Biologically active dietary polyamines" from University of South Bohemia, Faculty of Agriculture (2008)
"High PUT [putrescine] levels, even hundreds mg kg-1, were reported in citrus fruit and juices, ketchup, sauerkraut, fermented soybean products, ripened cheeses and fish sauce. Legumes, cauliflower, broccoli and cultivated mushrooms are foods with high SPD contents of tens mg kg-1. Beef, pork, meat products and legumes contain usually 20-40 mg kg-1 of SPM, the contents in chicken meat and particularly in porcine and chicken offal (liver, kidney, heart) are even higher. Commonly, PAs content range widely within individual food items. "
Showing posts with label epithelial restitution. Show all posts
Showing posts with label epithelial restitution. Show all posts
9.11.11
8.11.11
What is epithelial restitution?
"Epithelial restitution and wound healing in inflammatory bowel disease" In World J Gastrointerol (2008)
"Repeated damage and injury of the intestinal surface are key features of various intestinal disorders including inflammatory bowel diseases and require constant repair of the epithelium. Enhancement
of intestinal repair mechanisms by regulatory peptides or other modulatory factors may provide future approaches for the treatment of diseases that are characterized by injuries of the epithelial surface. ... Inflammatory processes especially may interfere with epithelial cell migration and proliferation and thus modulate intestinal epithelial healing."
"Pathophysiologic Rationale for Biological Therapies in IBD: Downstream Effector Mechanisms of Gut Damage and Repair" from Medscape News
"Matrix metalloproteinases (MMPs) are intimately involved in epithelial restitution and ulceration in the gutFlattened epithelial cells at the edge of ulcers secrete MMP-1 (interstitial collagenase), MMP-7 (matrilysin), and MMP-10 (stromelysin-2), presumably to allow them to remodel granulation tissue as they attempt to cover the ulcer. In the ulcer bed, fibroblasts secrete MMP-1 and MMP-13 (collagenase-3), as well as MMP-3 (stromelysin-1) and MMP-2 (gelatinase-A). Macrophages secrete MMP-10 and MMP-12 (metalloelastase). Careful thought will be needed in choosing MMP inhibitors to treat IBD. While inhibition may prevent MMP-mediated degradation of lamina propria matrix, it would not be helpful if the inhibition also prevented epithelial restitution."
"Repeated damage and injury of the intestinal surface are key features of various intestinal disorders including inflammatory bowel diseases and require constant repair of the epithelium. Enhancement
of intestinal repair mechanisms by regulatory peptides or other modulatory factors may provide future approaches for the treatment of diseases that are characterized by injuries of the epithelial surface. ... Inflammatory processes especially may interfere with epithelial cell migration and proliferation and thus modulate intestinal epithelial healing."
"Pathophysiologic Rationale for Biological Therapies in IBD: Downstream Effector Mechanisms of Gut Damage and Repair" from Medscape News
"Matrix metalloproteinases (MMPs) are intimately involved in epithelial restitution and ulceration in the gutFlattened epithelial cells at the edge of ulcers secrete MMP-1 (interstitial collagenase), MMP-7 (matrilysin), and MMP-10 (stromelysin-2), presumably to allow them to remodel granulation tissue as they attempt to cover the ulcer. In the ulcer bed, fibroblasts secrete MMP-1 and MMP-13 (collagenase-3), as well as MMP-3 (stromelysin-1) and MMP-2 (gelatinase-A). Macrophages secrete MMP-10 and MMP-12 (metalloelastase). Careful thought will be needed in choosing MMP inhibitors to treat IBD. While inhibition may prevent MMP-mediated degradation of lamina propria matrix, it would not be helpful if the inhibition also prevented epithelial restitution."
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