Does flavonoid supplementation improve Crohn's symptoms?

Flavonoid from Wikipedia

Flavinoid mind map from Wikipedia (flavanols, flavones, anthocyanidines, isoflavonoids, neoflavonoids)

Formerly known as vitamin P

Flavonoids from the world's healthiest foods
"Flavonoids, an amazing array of over 6,000 different substances found in virtually all plants, are responsible for many of the plant colors that dazzle us with their brilliant shades of yellow, orange, and red.....While the flavonoid family is too complex to report all of its food connections, some highlights are especially important. In the fruit family, it is berries that come out highest in the chemical category of flavonoids called anthocyanins. Black raspberries, for example, may contain up to 100 milligrams of anthocyanins per ounce. ... In general the more colorful components of the food--like the skins of fruits--contain the highest concentration of flavonoids."

"Emerging Role of Antioxidants in the Protection of Uveitis Complications" in Current Medicinal Chemistry (2011)
"Many studies suggest that dark colored fruits such as berries; including blackberry, raspberry, and strawberry are rich in flavonoids and polyphenolic compounds and are endowed with beneficial properties in vision and eye health. ... All these antioxidants described here are well known to control the production of reactive oxygen species as well as their dependent activation of redox-sensitive transcription factors such as NF-κB and AP1. Further, most of the flavinoids have shown to prevent the activation of several key enymes [sic] such as aldose reductase that controls the oxidative stress signals."

Does antioxidant dietary supplementation lessen inflammation in CD?

Antioxidants on Wikipedia
"An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When the chain reaction occurs in a cell, it can cause damage or death. ...
Although oxidation reactions are crucial for life, they can also be damaging; hence, plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, and vitamin E as well as enzymes such as catalase, superoxide dismutase and various peroxidases. Low levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells"

Oxidative Stress on Wikipedia
"Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of tissues can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Some reactive oxidative species can even act as messengers through a phenomenon called redox signaling.
In humans, oxidative stress is involved in many diseases. Examples include Sickle Cell Disease^[1], atherosclerosis, Parkinson's disease, heart failure, myocardial infarction, Alzheimer's disease, Schizophrenia, Bipolar disorder, fragile X syndrome^[2] and chronic fatigue syndrome, but short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.^[3] Reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens."

"Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease" in Am J Clin Nutr (2004)
"Dietary supplementation with fish oil plus antioxidants is associated with modified PBMC [peripheral blood mononuclear cell]composition and lower production of PGE2 [prostoglandin E2] and IFN-y [Interferon Gamma] by circulating monocytes or macrophages."


"The Effects of an Oral Supplement Enriched With Fish Oil, Prebiotics, and Antioxidants on Nutrition Status in Crohn’s Disease Patients" in Nutrition in Clinical Practice (2011)
"Background: Research in the treatment of Crohn’s disease (CD) supports anti-inflammatory benefits of n-3 fatty acids from fish oil, prebiotics, and antioxidants. A nutritionally balanced inflammatory bowel disease nutrition formula (IBDNF) enriched with these compounds has the potential to improve nutrition status and disease activity in CD. ...
Conclusions: IBDNF has the potential to deposit fat-free and fat mass, improve vitamin D status, and improve quality of life in CD patients."