Does olive oil reduce Crohn's imflammation?

Olive oil from Wikipedia

Polyphenol from Wikipedia

"Olive oil, extra virgin" from the world's healthiest foods
"The anti-inflammatory strength of olive oil rests on its polyphenols. These anti-inflammatory compounds include at least nine different categories of polyphenols and more than two dozen well-researched anti-inflammatory nutrients. Research has documented a wide variety of anti-inflammatory mechanisms used by olive oil polyphenols to lower our risk of inflammatory problems. These mechanisms include decreased production of messaging molecules that would otherwise increase inflammation (including TNF-alpha, interleukin 1-beta, thromboxane B2, and leukotriene B4); inhibition of pro-inflammatory enzymes like cyclo-oxygenase 1 and cyclo-oxygenase 2; and decreased synthesis of the enzyme inducible nitric oxide synthase.
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These anti-inflammatory benefits of extra virgin olive oil do not depend on large levels of intake. As little as 1-2 tablespoons of extra virgin olive oil per day have been shown to be associated with significant anti-inflammatory benefits."

Are resveratol and curcumin a dynamic duo?

"Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes" in Nutrition and Metabolism (2008) [full article]

"Curcumin and resveratrol treatment inhibited NF-κB activation and resulted in a reduction of TNF-α, IL-1β, IL-6, and COX-2 gene expression (IC50 = 2 μM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 μM).
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Curcumin and resveratrol are able to inhibit TNFα-activated NF-κB signaling in adipocytes and as a result significantly reduce cytokine expression. These data suggest that curcumin and resveratrol may provide a novel and safe approach to reduce or inhibit the chronic inflammatory properties of adipose tissue.
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Both polyphenols have relatively short half-lives in vivo as they are rapidly metabolized to their glucuronide and sulfated forms. These metabolites, readily found in the circulation, typically demonstrate very low cell permeability and questionable bioactivity when compared to their unmetabolized forms. In spite of these hurdles, the in vivo efficacies of curcumin and resveratrol have been reproducibly shown by numerous investigators. Many challenges lie ahead in order to systematically and quantitatively address the pharmacokinetics of these natural products. Immediate questions that need to be addressed to improve on in vivo efficacy include, 1) do the metabolites of curcumin and resveratrol have comparable bioactivity with the parent compounds, 2) does the circulating pool of metabolites represent a source of inhibitor that can be modified to their more active forms, and 3) can chemical substitutions be made to the base structures of curcumin and resveratrol making them more active and less susceptible to conjugation."

What is the significance of 2-styryl chromones in CD?

"Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways " in Biochemical Pharmacology (2009)
"The aim of the present work was to evaluate the anti-inflammatory potential of 2-styrylchromones (2-SC), a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), by studying their COX-1 and COX-2 inhibitory capacity as well as their effects on the LTB₄ [leukotrene B4] production by stimulated human polymorphonuclear leukocytes (PMNL). [granulocytes].
Some of the tested 2-SC were able to inhibit both COX-1 activity and LTB₄ production which makes them dual inhibitors of the COX and 5-LOX pathways. The most effective compounds in this study were those having structural moieties with proved antioxidant activity (3′,4′-catechol and 4′-phenol substituted B-rings).
This type of compounds may exhibit anti-inflammatory activity with a wider spectrum than that of classical non-steroidal anti-inflammatory drugs (NSAIDs) by inhibiting 5-LOX product-mediated inflammatory reactions, towards which NSAIDs are ineffective."

"Biological activities of 2-styrylchromones" in Mini Rev Med Chem (2010)
"2-Styrylchromones (2-SC) are chromone derivatives characterized by the attachment of a styryl group to the 2-position of the chromone structure. The 2-styrylchromone structure has been demonstrated to bear important biological activities such as antiallergic, antitumor, affinity and selectivity for A(3) adenosine receptors, antiviral, antioxidant and anti-inflammatory. The aim of the present paper was to review the available information on this field."

Do natural COX 2 inhibitors reduce Crohn's pain?

"Natural COX-2 Inhibitors The Future of Pain Relief" in Nutrition Science News (2000)
"A second factor holding back the progress of natural COX-2 inhibitors is their slow onset of relief. Unfortunately, there do not appear to be any natural anti-inflammatory/analgesic products that offer almost instantaneous relief of a magnitude close to aspirin or other NSAIDs. The consumer expectation of "relief in minutes" is destined to produce disappointment and derision if not adequately offset by education about these natural products. But if explained to them, the public will surely understand the virtue of natural products that provide gentle, effective, long-term relief."

How can PGE2 (prostaglandin E2) production and subsequent inflammation be minimized in CD?

"Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease" in Am J Clin Nutr (2004)
"Dietary supplementation with fish oil plus antioxidants is associated with modified PBMC [peripheral blood mononuclear cell]composition and lower production of PGE2 [prostoglandin E2] and IFN-y [Interferon Gamma] by circulating monocytes or macrophages."