Adverse Effects of Proton Pump Inhibitor Drugs: Clues and Conclusions: Abstract and Introduction
Risks Associated With Common Acid-Suppressing Medications Documented In Series of Studies
Showing posts with label medication. Show all posts
Showing posts with label medication. Show all posts
4.6.11
Sulphasalazine
Crohn’s disease (Review)" (2010)
Conclusions: "Sulfasalazine has modest efficacy compared to placebo and is inferior to corticosteroids for the treatment of mild to moderately active Crohn’s disease. Olsalazine and low dose mesalamine (1 to 2 g/day) are not superior to placebo. High dose mesalamine (3 to 4.5 g/day) is not more effective than placebo for inducing response or remission. High dose mesalamine was inferior to budesonide for inducing remission in a single trial. In conclusion, sulfasalazine shows modest efficacy for the treatment of active Crohn’s disease. However, the existing data show little benefit for 5-aminosalicylates."
Conclusions: "Sulfasalazine has modest efficacy compared to placebo and is inferior to corticosteroids for the treatment of mild to moderately active Crohn’s disease. Olsalazine and low dose mesalamine (1 to 2 g/day) are not superior to placebo. High dose mesalamine (3 to 4.5 g/day) is not more effective than placebo for inducing response or remission. High dose mesalamine was inferior to budesonide for inducing remission in a single trial. In conclusion, sulfasalazine shows modest efficacy for the treatment of active Crohn’s disease. However, the existing data show little benefit for 5-aminosalicylates."
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