"Nutrition Review - A Practical Guide to Avoiding Drug-Induced Nutrient Depletion, Cass in Nutrition Review [no date]
"Antibiotics deplete biotin, inositol, vitamins B1, B2, B3, B5, B6, B12 and vitamin K. Additionally, fluoroquinolones and all floxacins (including ciprofloxacin or “Cipro”) deplete calcium and iron. Tetracyclines (suffix, -cycline) deplete calcium and magnesium. Trimethoprim-containing antibiotics (brand names Trimpex, Proloprim or Primsol) deplete folic acid. Penicillins (suffix, -cillin) deplete potassium. Aminoglycosides, such as gentamicin, cause imbalances of magnesium, calcium and potassium. (20) In fact, one study showed that gentamicin causes increased excretion of calcium by 5 percent and magnesium by 8.4 percent. (21)
When you take antibiotics, consider a B vitamin complex along with it. Or take a multivitamin that contains 25 mg of B1 (thiamine), 25 mg of B2 (riboflavin), 50 mg of B3 (niacin), 50 mg of B6 (pyridoxine), 400 mcg to 800 mcg of folic acid, 10 mcg of B12, and 50 mg each of biotin and B5 (pantothenic acid).
Inositol is part of the B vitamin complex, and is likely to be included in a B vitamin or multivitamin formulation. Otherwise, take 500 mg of inositol. (The RDA is 100 mg per day.) In addition, either take a multivitamin that includes magnesium (500 mg), calcium (1,000 mg) and potassium (100 mg), or take them separately.
Antibiotics can disrupt the natural bacteria flora in the digestive system, killing “good” bacteria, including Lactobacillus acidophilus (L. acidophilus) and Bifidobacterium bifidum (B. bifidum). These are probiotics or bacteria that normally live in and on the human body, concentrated mostly in the digestive and genital/urinary systems. Choose a supplement that contains at least 1 billion live organisms per daily dose.
You also may consider 50 mcg daily of vitamin K, which is normally made by friendly intestinal bacteria. Vitamin K is required for proper blood clotting. Deficiency is rare, but when it occurs, life-threatening bleeding can occur from the smallest injury. Vitamin K also plays a part in osteoporosis prevention."
Showing posts with label calcium. Show all posts
Showing posts with label calcium. Show all posts
20.5.12
Does calcium supplementation improve Crohn's symptoms?
Hypercalcemia from Wikipedia
Hypercalciuria from Wikipedia
"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for ... calcium.... In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."
"Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: A pilot study" in Molecular Nutrition (2010)
"Vitamin D is the critical hormone for intestinal absorption of calcium. Optimal calcium absorption is important for proper mineralization of bone in the prevention of osteoporosis and osteoporotic fractures, among other important functions. Diseases associated with gut inflammation, such as Crohn's disease (CD), may impair calcium absorption. ... There was no significant difference in calcium FCA [fractional calcium absorption] at baseline or after increasing doses of calcitriol between the CD and controls. FCA in the control and CD group was approximately 35% at baseline, which increased to 60% after calcitriol therapy. No subject developed hypercalcemia or hypercalciuria. Our results suggest that CD patients have a normal response to vitamin D in enhancing the efficacy of calcium absorption. This suggests that stable CD patients can follow calcium and vitamin D guidelines of non-CD adults. Other factors independent of vitamin D status may impair intestinal calcium absorption in CD, including the degree and location of inflammation, presence of surgical resection and/or use of glucocorticoids."
are mainly related to the intake of macronutrients, energy and fiber and micronutrients, including calcium...."
"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for ... calcium.... In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."
"Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: A pilot study" in Molecular Nutrition (2010)
"Vitamin D is the critical hormone for intestinal absorption of calcium. Optimal calcium absorption is important for proper mineralization of bone in the prevention of osteoporosis and osteoporotic fractures, among other important functions. Diseases associated with gut inflammation, such as Crohn's disease (CD), may impair calcium absorption. ... There was no significant difference in calcium FCA [fractional calcium absorption] at baseline or after increasing doses of calcitriol between the CD and controls. FCA in the control and CD group was approximately 35% at baseline, which increased to 60% after calcitriol therapy. No subject developed hypercalcemia or hypercalciuria. Our results suggest that CD patients have a normal response to vitamin D in enhancing the efficacy of calcium absorption. This suggests that stable CD patients can follow calcium and vitamin D guidelines of non-CD adults. Other factors independent of vitamin D status may impair intestinal calcium absorption in CD, including the degree and location of inflammation, presence of surgical resection and/or use of glucocorticoids."
"Food intake in patients with Inflammatory Bowel Disease" in ABCD Arq Bras Cir Dig (2011) [full article]
"There was deficiency in food intake in both CD and UC in active and in remission. These deficienciesare mainly related to the intake of macronutrients, energy and fiber and micronutrients, including calcium...."
25.1.12
Do blueberries reduce Crohn's symptoms?
Blueberries from the world's healthiest foods
"Protective Effect of Anthocyanins Extract from Blueberry on TNBS-Induced IBD Model of Mice" in Evidence-Based Complementary and Alternative Medicine (2011) [full article]
"Blueberries are among the fruits that are best recognized for their potential health benefits [1], and many of the heath-promoting properties of blueberries are thought to be attributable to anthocyanins that structurally belong to the natural products of flavonoids (Figure 1). Anthocyanins are water-soluble pigments that might appear as red, purple or blue pigments according to their pH levels and are present in blueberries at high concentrations [2]. Anthocyanins from blueberries are also used as anti-inflammatory, antimutagenic and rhodophylactic agents, and the principal therapeutic benefits attributable to anthocyanins include antioxidant protection and maintenance of DNA integrity [3, 4].
...
Thus, evaluation of the protective effect of anthocyanins extract of blueberry on IBD might shed light on drug discovery or alternative therapy for IBD treatment.
Thus, evaluation of the protective effect of anthocyanins extract of blueberry on IBD might shed light on drug discovery or alternative therapy for IBD treatment.
...
Our results suggest that the protective effect of anthocyanins extract may be linked to the re-equilibration of the irregular expression of cytokines induced by colitis. Therefore, we can presume that the high-dose intake of anthocyanins extract from blueberries (or blueberries) can have some beneficial effects on IBD."
Anthocyanin on Wikipedia
"The aim of our studies was to determine the amount of polyphenols reaching the colon after oral intake of apple juice and blueberries.... A higher amount of the blueberry anthocyanins under study (up to 85%, depending on the sugar moiety) were determined in the ileostomy bags and therefore would reach the colon under physiological circumstances. Such structure-related availability has to be considered when polyphenols are used in model systems to study potential preventive effects in colorectal diseases."
Probiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis in Digestive Diseases and Sciences (2008)
"Cecal Enterobacteriaceae count decreased significantly in blueberry with and without probiotics compared to the other groups."
"Chemoprevention of Chronic Inflammatory Bowel Disease-Induced Carcinogenesis in Rodent Models by Berries" in Berries and Cancer Prevention (2011)
"Long-term chronic inflammation including inflammatory bowel disease is a well-recognized risk factor for cancer development. Fresh fruits, particularly berries, have been well documented as having protective effects against inflammation and cancer development. There are several key elements in the berries with functions against cancer, including vitamins (A, C, E, and folic acid), minerals (calcium and selenium), phenol compounds (particularly ellagic acid, ferulic acid, chlorogenic acid, coumaric acid, quercetin and anthocyanins), phytosterols (β-sitosterol, campesterol, and stigmasterol) and oligosaccharides. This chapter focuses on linking berries to chronic colitis-induced carcinogenesis from experimental evidence to potential usefulness on cancer prevention and treatment."
"Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a−/− mice, a model of inflammatory bowel diseases" in Nutrition (2012)
"In comparison to mice fed the control diet, blueberry and broccoli supplementation altered cecum microbiota similarly with the exception of Faecalibacterium prausnitzii, which was found to be significantly lower in broccoli-fed mice. High concentrations of butyric acid and low concentrations of succinic acid were observed in the cecum of broccoli-fed mice. Blueberry- and broccoli-supplemented diets increased colon crypt size and the number of goblet cells per crypt. Only the broccoli-supplemented diet significantly lowered colonic inflammation compared to mice fed the control diet. Translocation of total microbes to mesenteric lymph nodes was lower in broccoli-fed mice compared to blueberry and control diet groups."
18.1.12
Are micronutrient levels lower in Crohn's?
"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements" in Am J Clin Nutrition (2012)
"Except for copper and vitamin E, all plasma micronutrient concentrations decreased with increasing severities of the acute inflammatory response. For selenium and vitamins B-6 and C, this occurred with only slightly increased C-reactive protein concentrations of 5 to 10 mg/L. For each micronutrient, the change in plasma concentrations varied markedly from patient to patient. The magnitude of the effect was greatest for selenium and vitamins A, B-6, C, and D, for which the median plasma concentrations decreased by >40%."
"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for folate, vitamins C, E, and calcium. ... In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."
"The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease" in Cent Afr J Med (2002)
"Children with IBD in this study show abnormalities of the trace elements which is probably a result of inadequate intake, reduced absorption, increased intestinal loss due to impairment of the absorption as a result of the inflammatory process. The reduced free radical scavenging action of zinc and selenium as a result of their deficiency may contribute to the continued inflammatory process of IBD. The recommendation of the supplementation of these trace elements in IBD is further supported by the findings of this study in children."
"Except for copper and vitamin E, all plasma micronutrient concentrations decreased with increasing severities of the acute inflammatory response. For selenium and vitamins B-6 and C, this occurred with only slightly increased C-reactive protein concentrations of 5 to 10 mg/L. For each micronutrient, the change in plasma concentrations varied markedly from patient to patient. The magnitude of the effect was greatest for selenium and vitamins A, B-6, C, and D, for which the median plasma concentrations decreased by >40%."
"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for folate, vitamins C, E, and calcium. ... In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."
"The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease" in Cent Afr J Med (2002)
"Children with IBD in this study show abnormalities of the trace elements which is probably a result of inadequate intake, reduced absorption, increased intestinal loss due to impairment of the absorption as a result of the inflammatory process. The reduced free radical scavenging action of zinc and selenium as a result of their deficiency may contribute to the continued inflammatory process of IBD. The recommendation of the supplementation of these trace elements in IBD is further supported by the findings of this study in children."
1.12.11
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