"Epithelial restitution and wound healing in inflammatory bowel disease" In World J Gastrointerol (2008)
"Repeated damage and injury of the intestinal surface are key features of various intestinal disorders including inflammatory bowel diseases and require constant repair of the epithelium. Enhancement
of intestinal repair mechanisms by regulatory peptides or other modulatory factors may provide future approaches for the treatment of diseases that are characterized by injuries of the epithelial surface. ... Inflammatory processes especially may interfere with epithelial cell migration and proliferation and thus modulate intestinal epithelial healing."
"Pathophysiologic Rationale for Biological Therapies in IBD: Downstream Effector Mechanisms of Gut Damage and Repair" from Medscape News
"Matrix metalloproteinases (MMPs) are intimately involved in epithelial restitution and ulceration in the gutFlattened epithelial cells at the edge of ulcers secrete MMP-1 (interstitial collagenase), MMP-7 (matrilysin), and MMP-10 (stromelysin-2), presumably to allow them to remodel granulation tissue as they attempt to cover the ulcer. In the ulcer bed, fibroblasts secrete MMP-1 and MMP-13 (collagenase-3), as well as MMP-3 (stromelysin-1) and MMP-2 (gelatinase-A). Macrophages secrete MMP-10 and MMP-12 (metalloelastase). Careful thought will be needed in choosing MMP inhibitors to treat IBD. While inhibition may prevent MMP-mediated degradation of lamina propria matrix, it would not be helpful if the inhibition also prevented epithelial restitution."
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