"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements" in Am J Clin Nutrition (2012)
"Except for copper and vitamin E, all plasma micronutrient concentrations decreased with increasing severities of the acute inflammatory response. For selenium and vitamins B-6 and C, this occurred with only slightly increased C-reactive protein concentrations of 5 to 10 mg/L. For each micronutrient, the change in plasma concentrations varied markedly from patient to patient. The magnitude of the effect was greatest for selenium and vitamins A, B-6, C, and D, for which the median plasma concentrations decreased by >40%."
"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for folate, vitamins C, E, and calcium. ... In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."
"The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease" in Cent Afr J Med (2002)
"Children with IBD in this study show abnormalities of the trace elements which is probably a result of inadequate intake, reduced absorption, increased intestinal loss due to impairment of the absorption as a result of the inflammatory process. The reduced free radical scavenging action of zinc and selenium as a result of their deficiency may contribute to the continued inflammatory process of IBD. The recommendation of the supplementation of these trace elements in IBD is further supported by the findings of this study in children."
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