See gingerol on Wikipedia
"Curcumin: Getting Back to the Roots" by Shishodia et al., Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas
"Modern science has revealed that curcumin mediates its effects by modulation of several important molecular targets, including transcription factors (e.g., NF- B, AP-1, Egr-1, -catenin, and PPAR- ), enzymes (e.g., COX2, 5-LOX, iNOS, and hemeoxygenase-1), cell cycle proteins (e.g., cyclin D1 and p21), cytokines (e.g., TNF, IL-1, IL-6, and chemokines), receptors (e.g., EGFR and HER2), and cell surface adhesion molecules. Because it can modulate the expression of these targets, curcumin is now being used to treat cancer, arthritis, diabetes, Crohn’s disease, cardiovascular diseases, osteoporosis, Alzheimer’s disease, psoriasis, and other pathologies. Interestingly, 6-gingerol, a natural analog of curcumin derived from the root of ginger (Zingiber officinalis), exhibits a biologic activity profile similar to that of curcumin. The efficacy, pharmacologic safety, and cost effectiveness of curcuminoids prompt us to “get back to our roots."
"Ginger May Reduce Colorectal Cancer Risk" in Natural Medicine Journal (2012)
"The first is that ginger acts as an anti-inflammatory and blocks both cyclooxygenase (COX) and lipoxygenase (LOX) enzymes that produce procancer eicosanoids. Aspirin protects against CRC, and it only blocks the COX enzymes. Evidence suggests that inhibiting both the COX and the LOX pathways will slow tumor growth more than inhibiting either pathway alone.
The second is that ginger has antitumor action independent of these anti-inflammatory effects. “The cancer preventive activities of ginger are supposed to be mainly due to free radical scavenging, antioxidant pathways, alteration of gene expressions, and induction of apoptosis, all of which contribute towards decrease in tumor initiation, promotion, and progression.”1 An extract of “ginger, can enhance the anticancer effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).” Ginger extract “potentiated TRAIL-induced apoptosis in human HCT116 colon cancer cells and … this correlated with the up-regulation of TRAIL death receptor (DR) 4 and DR5.” This was “not cell-type specific, as its expression was also up-regulated in prostate, kidney, breast, and pancreatic cancer cell lines.”2"
"Ginger May Reduce Colorectal Cancer Risk" in Natural Medicine Journal (2012)
"The first is that ginger acts as an anti-inflammatory and blocks both cyclooxygenase (COX) and lipoxygenase (LOX) enzymes that produce procancer eicosanoids. Aspirin protects against CRC, and it only blocks the COX enzymes. Evidence suggests that inhibiting both the COX and the LOX pathways will slow tumor growth more than inhibiting either pathway alone.
The second is that ginger has antitumor action independent of these anti-inflammatory effects. “The cancer preventive activities of ginger are supposed to be mainly due to free radical scavenging, antioxidant pathways, alteration of gene expressions, and induction of apoptosis, all of which contribute towards decrease in tumor initiation, promotion, and progression.”1 An extract of “ginger, can enhance the anticancer effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).” Ginger extract “potentiated TRAIL-induced apoptosis in human HCT116 colon cancer cells and … this correlated with the up-regulation of TRAIL death receptor (DR) 4 and DR5.” This was “not cell-type specific, as its expression was also up-regulated in prostate, kidney, breast, and pancreatic cancer cell lines.”2"
See my post entitled "Can Curcumin reduce Crohn's symptoms?"
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