"Prodromal Irritable Bowel Syndrome May Be Responsible for Delays in Diagnosis in Patients Presenting with Unrecognized Crohn’s Disease and Celiac Disease, but Not Ulcerative Colitis" in Digestive diseases and sciences (2011)
" This is the first study to make direct comparisons of prodrome periods between celiac disease and IBD. Prodrome duration in celiac disease is significantly longer and more often characterized by P-IBS than IBD. In celiac disease and CD, P-IBS increases prodrome duration. This may represent a failure to understand the overlap between IBS and celiac disease/IBD."
" This is the first study to make direct comparisons of prodrome periods between celiac disease and IBD. Prodrome duration in celiac disease is significantly longer and more often characterized by P-IBS than IBD. In celiac disease and CD, P-IBS increases prodrome duration. This may represent a failure to understand the overlap between IBS and celiac disease/IBD."
"The Manitoba Inflammatory Bowel Disease Cohort Study: Prolonged Symptoms Before Diagnosis—How Much Is Irritable Bowel Syndrome?" in Clinical Gastroenterology and Hepatology (2006)
"Background & Aims: The Manitoba Inflammatory Bowel Disease (IBD) Cohort Study is a population-based prospective cohort study of recently diagnosed IBD (n = 396). At enrollment, 162 (41%) indicated gastrointestinal symptom ≥3 years before diagnosis. We aimed to determine whether coexistence of irritable bowel syndrome (IBS) had a role in symptoms before IBD diagnosis.
Conclusions: These data suggest that older patients and those with likely and possible preexisting IBS are more likely to experience longer symptom duration before diagnosis of IBD. The prevalence rate of IBS was similar to estimated base rates in the general population."
Conclusions: These data suggest that older patients and those with likely and possible preexisting IBS are more likely to experience longer symptom duration before diagnosis of IBD. The prevalence rate of IBS was similar to estimated base rates in the general population."
"Isolated Ileal Erosions in Pts With Mildly Altered Bowel Habits: Discussion" from Medscape Today (2006)
"These cases raise the issue of the appropriate diagnostic approach in this situation. There are no formal guidelines about whether similar lesions should be classified by pathologists as nonspecific or as "suggestive of Crohn disease." One option is to use the diagnosis of "isolated ileal erosion" and add a comment stating "this lesion is idiopathic in most patients; however, in approximately one third, the disease will eventuate into typical Crohn disease, often after a prolonged interval."
"Identification of a prodromal period in Crohn's disease but not ulcerative colitis" in The American Journal of Gastroenterology (2000)
"There is a significant prodromal period before the time of diagnosis of Crohn's disease that is not found in ulcerative colitis even after exclusion of subjects with IBS."
"Family studies in Crohn's disease: new horizons in understanding disease pathogenesis, risk and prevention" in Gut (2011)
"Specific physiological abnormalities associated with CD, such as increased intestinal permeability and raised faecal calprotectin, are also abnormal in some relatives of patients with CD. The combination of genotypic factors and biomarkers of risk makes the development of models of disease prediction a realistic possibility. Furthermore, enhanced understanding of the genotype and phenotype of the at-risk state in relatives of patients with CD allows the earliest stages in the pathogenesis of CD to be investigated and may allow intervention to prevent disease onset."
"Family studies in Crohn's disease: new horizons in understanding disease pathogenesis, risk and prevention" in Gut (2011)
"Specific physiological abnormalities associated with CD, such as increased intestinal permeability and raised faecal calprotectin, are also abnormal in some relatives of patients with CD. The combination of genotypic factors and biomarkers of risk makes the development of models of disease prediction a realistic possibility. Furthermore, enhanced understanding of the genotype and phenotype of the at-risk state in relatives of patients with CD allows the earliest stages in the pathogenesis of CD to be investigated and may allow intervention to prevent disease onset."
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