"Apigenin (4’,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. It is a yellow crystalline solid that has been used to dye wool. Apigenin may contribute to the chemopreventive action of vegetables and fruits.[2] It was recently shown that apigenin induces a process called autophagia (a kind of cellular dormancy) that may well explain its chemopreventive properties, but at the same time it induces resistance against chemotherapy.[3] Apigenin is a potent inhibitor of CYP2C9,[4] an enzyme responsible for the metabolism of many pharmaceutical drugs in the body."
"Anti-inflammatory activity of structurally related flavonoids,Apigenin, Luteolin and Fisetin" in International Immunopharmacology (2011)
"Flavonoids are widely distributed in many fruits and plants, and it has been shown that most flavonoids have anti-inflammatory activity; however, the mechanisms of how the flavonoids exhibit their anti-inflammatory activity have not been clarified. We therefore focus on flavonoids Apigenin, Luteolin and Fisetin because of their related structure. We found that these compounds significantly inhibited TNFα-induced NF-κB transcriptional activation; however, they had no effect on the degradation of IκB proteins and the nuclear translocation and DNA binding activity of NF-κB p65 [IFDR1]."
"Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-κB in an intestinal epithelial cell line (IEC18)" in British Journal of Pharacology (2010)"Apigenin exhibited an apparent trend for higher induction of COX-2 at 100 µM,..."
No comments:
Post a Comment