21.11.11

Do NSAIDs influence Crohn's?

NSAIDs Can Raise Risk for Crohn's Disease:

"NSAID-induced intestinal damage: are luminal bacteria the therapeutic target?" Commentary in Gut (2008)
"Although the upper gastrointestinal (GI) toxicity of NSAIDs is well documented, the appreciation that NSAID damage extends beyond the duodenum is less well recognised. NSAID-associated toxicity to the small and large bowel has several different manifestations, including sub-clinical and clinically evident damage ( table 1 ).  The prevalence of NSAID-associated lower GI side effects may exceed that detected in the upper GI tract and the frequency of life-threatening complications due to the lower GI tract represents nowadays no less than a third of all GI complications associated with the use of these agents. 5 NSAIDs may also exacerbate underlying diseases, such as inflammatory bowel disease (IBD), which is a difficult clinical problem since many patients suffer from both IBD and arthritic diseases." [Emphasis mine.]

Bacterial flora in digestive disease: focus on rifaximin, "Antibiotics for NSAID Enteropathy"

Aspirin in the Etiology of Crohn's disease and UC : Abstract and Introduction







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