4.6.11

Does Vitamin D have a role in CD?

vitamin D from the world's healthiest foods

vitamin D from Wikipedia

"Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer" in Therapeutic Advances in Gastroenterology (2011)
"Over the past 5 years, there has been a rapid resurgence of interest in vitamin D outside of its traditional role in metabolic bone disease. Some nontraditional roles ascribed to vitamin D include anti-inflammatory and immune-modulating effects. These effects have led to possible implications in the pathophysiology of immune-mediated diseases including multiple sclerosis and inflammatory bowel disease (IBD)."

"Effects of Supplemental Vitamin D and Calcium on Biomarkers of Inflammation in Colorectal Adenoma Patients: A Randomized, Controlled Clinical Trial" in Cancer Prev Res (2011)
"These preliminary results are consistent with a pattern of reduction in tumor-promoting inflammation biomarkers with vitamin D3 or calcium supplementation alone and support further investigation of vitamin D3 as a chemopreventive agent against inflammation and colorectal neoplasms."

"Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier" in Am. J. Physiol. Gastrointest. Liver Physiol (2010)
"Emerging evidence supports a pathological link between vitamin D deficiency and the risk of inflammatory bowel disease (IBD). ...VDR [Vitamin D Receptor] plays a critical role in mucosal barrier homeostasis by preserving the integrity of junction complexes and the healing capacity of the colonic epithelium. Therefore, vitamin D deficiency may compromise the mucosal barrier, leading to increased susceptibility to mucosal damage and increased risk of IBD"

"Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn's Disease" in J Bio Chem (2009)
"These studies provide strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition, as Crohn's pathogenesis is associated with attenuated NOD2 or DEFB2/HBD2 function."

"Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study" in Am J Epidemiol (2007)
"The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation."

"Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3 in subjects receiving a high-fibre diet" in Br J Nutr (1983)


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