Trends in Immunology : Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease in Trends in Immunology (2010)
From Abstract: "Candida albicans is a diploid fungus that colonizes the gastrointestinal tract asymptomatically in a large proportion of the human population, but can cause life-threatening conditions in immunocompromised patients. ... [W]e propose a pathophysiological model whereby a defective NLRP3-coupled inflammasome can result in enhanced mucosal colonization of granuloma-provoking microorganisms, including C. albicans, precipitating the formation of Crohn's disease-associated inflammatory lesions."
No comments:
Post a Comment