How can bioavailability be improved in Crohn's?

Premeal drink of a fatty acid mixed in a nutritional supplement
Inflammatory bowel disease: from bench to bedside, Targon et al. (2005)
"We have shown recently that abnormally rapid transit contributes to poor bioavailability of an oral drug in IBD patients with chronic diarrhea, and that drug bioavailability can be readily and safely increased with the fatty acid-based therapy." (
"... this therapy is directed specifically at slowing gastro-intestinal transit, an important beneficial side-effect of this therpy is increased contact time of the luminal contents with digestive enzymes and absorptive surfaces.  In addition to improving diarrhea, this therapy is likely to improve nutrition by increasing digestion and absorption of a meal. ... the end products of fat digestion are the most potent nutrient triggers of the intestinal brake system" (p. 597)