"Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. ...
Cancer Prevention ... The strongest evidence of anti-cancer action of resveratrol exists for tumors it can come into direct contact with, such as skin and gastrointestinal tract tumors. ... Thus, resveratrol (1 mg/kg orally) reduced the number and size of the esophageal tumors in rats treated with a carcinogen.;[24] and in several studies, small doses (0.02–8 mg/kg) of resveratrol, given prophylactically, reduced or prevented the development of intestinal and colon tumors in rats given different carcinogens. ...
Anti-inflammatory effects: The anti-inflammatory effects of resveratrol have been demonstrated in several animal model studies. In a rat model of carrageenan-induced paw edema, resveratrol inhibited both acute and chronic phases of the inflammatory process.[36] Similarly, preincubation with resveratrol decreased arachidonic acid release and COX-2 induction in mouse peritoneal macrophages stimulated with tumor promoter PMA, ROI, or lipopolysaccharides (LPS).[37] In an experimental rabbit inflammatory arthritis model, resveratrol showed promise as a potential therapy for arthritis. When administered to rabbits with induced inflammatory arthritis, resveratrol protected cartilage against the progression of inflammatory arthritis. ...
In grapes, resveratrol is found primarily in the skin, and—in muscadine grapes—also in the seeds.[141] The amount found in grape skins also varies with the grape cultivar, its geographic origin, and exposure to fungal infection. The amount of fermentation time a wine spends in contact with grape skins is an important determinant of its resveratrol content. ... Reports suggest that some aspect of the wine making process converts piceid to resveratrol in wine, as wine seems to have twice the average resveratrol concentration of the equivalent commercial juices. ...
In general, wines made from grapes of the Pinot Noir and St. Laurent varieties showed the highest level of trans-resveratrol, though no wine or region can yet be said to produce wines with significantly higher resveratrol concentrations than any other wine or region."
What is resveratol? in the world's healthiest foods
"Resveratrol is a unique phytonutrient that is found in grapes, cranberries, blueberries, peanuts, jackfruit, mulberries, bilberries, lingonberries, and a wide range of other non-food plants including flowers and trees. ... Choose red or purple grapes instead of green ones. Although green grapes contain resveratrol, they contain much less that the red or purple varieties."
My Resveratol Experience
"Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties" in Yonsei Med J (2005)
"The stillbene compound resveratol possesses anti-inflammatory activity because it suppresses carragenen-induced pedal edema via the inhibition of COX activity. Furthermore, resveratrol inhibits TPA-induced COX-2 expression at the transcriptional level.23 Thus, the mechanism by which resveratrol exerts anti-inflammatory activity may be related to the inhibition of either COX transcription or COX activity. ...EGCG [epigallocatechin gallate] and resveratrol were the most effective COX-1 inhibitors among those tested in the study."
"Dietary polyphenols can modulate the intestinal inflammatory response" in Nutrition Reviews (2009)
"Studies, conducted using in vivo and in vitro models, provide evidence that pure polyphenolic compounds and natural polyphenolic plant extracts can modulate intestinal inflammation."
"Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation" in PLoS ONE (2010)
"Oral treatment with Resveratrol, Curcumin or Simvastatin ameliorates acute small intestinal inflammation by down-regulating Th1-type immune responses and prevents bacterial translocation by maintaining gut barrier function. These findings provide novel and potential prophylaxis and treatment options of patients with inflammatory bowel diseases."
"Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohn's disease" in Inflammatory Bowel Disease (2011)
"Resveratrol has antiinflammatory and antifibrotic effects. Resveratrol decreases proliferation and collagen synthesis by intestinal smooth muscle cells. ... Resveratrol decreases inflammatory cytokines and TGF-β1 in the PG-PS model of Crohn's disease and demonstrates a promising trend in decreasing tissue fibrosis. These findings may have therapeutic applications in inflammatory bowel disease."
"Resveratrol causes cell cycle arrest, decreased collagen synthesis, and apoptosis in rat intestinal smooth muscle cells" in Gastrointestinal and Liver Physiology (2011)
"One of the most difficult and treatment-resistant complications of Crohn's disease is the development of fibrotic intestinal strictures due to mesenchymal cell hyperplasia and collagen deposition. Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, has been shown to inhibit fibrosis in vasculature, heart, lung, kidney, liver, and esophagus in animal models. Resveratrol has also been shown to inhibit oxidation, inflammation, and cell proliferation and to decrease collagen synthesis in several cell types or animal models. ... Thus, resveratrol decreases intestinal smooth muscle cell numbers through its effects on cell cycle arrest and apoptosis, and also decreases collagen synthesis by the cells. These effects could be useful in preventing the smooth muscle cell hyperplasia and collagen deposition that characterize stricture formation in Crohn's disease."
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