"Serum Antibodies to Mycobacterium avium Subspecies paratuberculosis Combined with Anti-Saccharomyces cerevisiae Antibodies in Crohn’s Disease Patients: Prevalence and Diagnostic Role" in Digestive Diseases and Sciences (2010)
Background: "Because Mycobacterium avium subspecies paratuberculosis (MAP), the etiologic agent of Johne’s disease in ruminant, has been identified in the mucosal layer and deeper bowel wall in CD patients, the seroactivity against MAP may define a distinct subset of patients requiring individual treatment. The aim of this study was to assess the performance of anti-MAP antibodies in the diagnostic strategy for CD."
Results: " No correlation was found between anti-MAP positivity and clinical features such as age at onset and the duration of CD, disease location, or intestinal complications. Conversely, extra-intestinal manifestations of CD were statistically associated with a positivity of anti-MAP (48% vs. 24%, P = 0.028), mostly with respect to arthritis (44.5% vs. 13%, P < 0.002)."
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