20.5.12

Does vitamin E supplementation improve Crohn's symptoms?

Vitamin E from Wikipedia

Vitamin E from CyberLipid Center
"The term "vitamin E" should be used for all tocopherol, tocotrienol and tocomonoenol derivatives exhibiting the biological activity of d-a-tocopherol. The term "tocopherol" should be used for all methyl tocols. Since tocotrienols have some vitamin E activity, "tocopherol" is not synonymous with "vitamin E"."

"Advanced Plan: Supplements" from Mercola.com
"Keep in mind that your body can easily distinguish between natural and synthetic vitamins, and natural vitamin E is between two and three times as bioactive as the same amount of synthetic vitamin E. Natural vitamin E is always listed as the "d-" form (d-alpha-tocopherol, d-beta-tocopherol, etc.). Synthetic vitamin E is listed as " dl-" forms.

But your optimal source for vitamin E is from your food. A 2002 study suggested that if you consume plenty of vegetables (about one pound of vegetables for every 50 pounds of body weight), the antioxidants in the vegetables may provide as much, or more, protection as vitamin E supplements."

"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for folate, vitamins C, E, and calcium. ...  In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."

"Food intake in patients with Inflammatory Bowel Disease" in ABCD Arq Bras Cir Dig (2011) [full article]
"There was deficiency in food intake in both CD and UC in active and in remission. These deficiencies
are mainly related to the intake of macronutrients, energy and fiber and micronutrients, including ... tocopherol...."

"A Novel Water-Soluble Vitamin E Derivative Protects Against Experimental Colitis in Rats" in
Antioxidants & Redox Signaling (2008)
"This study was designed to investigate the effects of water-soluble vitamin E derivative, 2-(α-d-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol (TMG), on experimental colitis in rats. ... These results suggest that TMG is effective for the treatment of colitis in rats induced by TNBS [trinitrobenzene sulfonic acid]."

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