"Protective effect of taurine on TNBS-induced inflammatory bowel disease in rats" in Arch Pharm Res (1998)
"Taurine treatment decreased both basal and formyl-methionyl leucyl phenylalanine-stimulated reactive oxygen generation from colonic tissue in the IBD rats. These results suggest that the administration of taurine reduce the inflammatory parameters in this IBD rat model by increasing defending capacity against oxidative damage."
"Effect of taurine on oxidative stress and apoptosis-related protein expression in trinitrobenzene sulphonic acid-induced colitis" in Clinical & Experimental Immunology (2008) [fulll article]
"Taurine treatment was associated with amelioration in macroscopic and microscopic colitis scores, decreased colonic MPO [myeloperoxidase] activity and MDA [malondialdehyde] levels and increased GSH [glutathione] levels in TNBS-induced colitis. In addition, taurine reduced the expression of Bax and prevented the loss of Bcl-2 proteins in colon tissue of rats with TNBS-induced colitis. The results of this study show that taurine administration may exert beneficial effects in UC by decreasing inflammatory reactions, oxidative stress and apoptosis.
...
Because cysteine is a precursor of taurine and GSH, taurine supplementation may cause enhancement in GSH levels by directing cysteine into the GSH synthesis pathway [13,23]. Therefore, increased GSH levels after taurine treatment may play an additional role in decreasing oxidative stress. In our study, a significant decrease in colonic MDA levels and an increase in GSH levels were detected in rats with TNBS-induced colitis following taurine treatment.
...
Therefore, it is speculated that taurine treatment ameliorates TNBS-induced colitis by reducing pro-apoptotic pathway activation and preventing the loss of the anti-apoptotic pathway through inhibition of oxidative stress."
"Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers" in Biomedical and Life Sciences (2008)
"Taurine supplementation significantly attenuated the weight decrease, diarrhea severity, colon shortening, and the increase in the colonic tissue myeloperoxidase activity induced by DSS. Taurine also significantly inhibited the increase in the expression of a pro-inflammatory chemokine, macrophage inflammatory protein 2 (MIP-2), but not of interleukin (IL)-1β or tumor necrosis factor (TNF)-α mRNA. Furthermore, taurine significantly protected the intestinal Caco-2 cell monolayers from the damage by macrophage-like THP-1 cells in an in vitro coculture system. These results suggest that taurine prevented DSS-induced colitis partly in association with (1) its inhibitory effects on the secretion of MIP-2 from the intestinal epithelial cells and on the infiltration of such inflammatory cells as neutrophils and (2) its cytoprotective functions on the epithelial barrier from the direct toxicity of DSS and from the inflammatory cell-induced injury."
"Taurine treatment was associated with amelioration in macroscopic and microscopic colitis scores, decreased colonic MPO [myeloperoxidase] activity and MDA [malondialdehyde] levels and increased GSH [glutathione] levels in TNBS-induced colitis. In addition, taurine reduced the expression of Bax and prevented the loss of Bcl-2 proteins in colon tissue of rats with TNBS-induced colitis. The results of this study show that taurine administration may exert beneficial effects in UC by decreasing inflammatory reactions, oxidative stress and apoptosis.
...
Because cysteine is a precursor of taurine and GSH, taurine supplementation may cause enhancement in GSH levels by directing cysteine into the GSH synthesis pathway [13,23]. Therefore, increased GSH levels after taurine treatment may play an additional role in decreasing oxidative stress. In our study, a significant decrease in colonic MDA levels and an increase in GSH levels were detected in rats with TNBS-induced colitis following taurine treatment.
...
Therefore, it is speculated that taurine treatment ameliorates TNBS-induced colitis by reducing pro-apoptotic pathway activation and preventing the loss of the anti-apoptotic pathway through inhibition of oxidative stress."
"Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers" in Biomedical and Life Sciences (2008)
"Taurine supplementation significantly attenuated the weight decrease, diarrhea severity, colon shortening, and the increase in the colonic tissue myeloperoxidase activity induced by DSS. Taurine also significantly inhibited the increase in the expression of a pro-inflammatory chemokine, macrophage inflammatory protein 2 (MIP-2), but not of interleukin (IL)-1β or tumor necrosis factor (TNF)-α mRNA. Furthermore, taurine significantly protected the intestinal Caco-2 cell monolayers from the damage by macrophage-like THP-1 cells in an in vitro coculture system. These results suggest that taurine prevented DSS-induced colitis partly in association with (1) its inhibitory effects on the secretion of MIP-2 from the intestinal epithelial cells and on the infiltration of such inflammatory cells as neutrophils and (2) its cytoprotective functions on the epithelial barrier from the direct toxicity of DSS and from the inflammatory cell-induced injury."
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