20.5.12

Does calcium supplementation improve Crohn's symptoms?


Calcium from Wikipedia

Hypercalcemia from Wikipedia

Hypercalciuria from Wikipedia

"Adequacy of Nutritional Intake in a Canadian Population of Patients with Crohn’s Disease" in Journal of the American Dietetic Association (2007)
"Micronutrient intakes were suboptimal most notably for ... calcium....  In conclusion, in this population sample, a large number of ambulatory patients with Crohn’s disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population."

"Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: A pilot study" in Molecular Nutrition (2010)
"Vitamin D is the critical hormone for intestinal absorption of calcium. Optimal calcium absorption is important for proper mineralization of bone in the prevention of osteoporosis and osteoporotic fractures, among other important functions. Diseases associated with gut inflammation, such as Crohn's disease (CD), may impair calcium absorption. ... There was no significant difference in calcium FCA [fractional calcium absorption] at baseline or after increasing doses of calcitriol between the CD and controls. FCA in the control and CD group was approximately 35% at baseline, which increased to 60% after calcitriol therapy. No subject developed hypercalcemia or hypercalciuria. Our results suggest that CD patients have a normal response to vitamin D in enhancing the efficacy of calcium absorption. This suggests that stable CD patients can follow calcium and vitamin D guidelines of non-CD adults. Other factors independent of vitamin D status may impair intestinal calcium absorption in CD, including the degree and location of inflammation, presence of surgical resection and/or use of glucocorticoids."

"Food intake in patients with Inflammatory Bowel Disease" in ABCD Arq Bras Cir Dig (2011) [full article]
"There was deficiency in food intake in both CD and UC in active and in remission. These deficiencies
are mainly related to the intake of macronutrients, energy and fiber and micronutrients, including calcium...."

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