29.4.12

Does acetylcysteine supplementation improve Crohn's symptoms?

Acetylcysteine aka N-acetylcysteine or N-acetyl-L-cysteine (NAC) from Wikipedia

"Molecular evidences on the benefit of N-acetylcysteine in experimental colitis" in Central European Journal of Biology (2008)
"It is concluded that moderate to high doses of NAC improves cellular biomarkers of IBD in mice. Further studies should be trialled in humans suffering from two common inflammatory bowel disease called ulcerative colitis and Crohn’s disease."

"N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study" in World J Gasterol (2008)
"In conclusion, the results of the present pilot study suggest that combined therapy (NAC and mesalamine) produces a clinical improvement of UC patients which correlates with a decrease of MCP-1 and IL8. However, the difference in clinical effect with respect to the control group (mesalamine alone) is not conclusive. NAC is safe and well tolerated."

No comments: