19.3.12

Does increasing linoleic acid decrease Crohn's symptoms?

Linoleic Acid on Wikipedia

"Conjugated linoleic modulates immune responses in patients with Mild to Moderately active Crohn's disease" in Clinical Nutrition (2012).
"CLA is an example of an anti-inflammatory compound in a pipeline of naturally occurring and synthetic compounds (e.g., abscisic acid, eleostearic acid, terephthalanilides) with tremendous therapeutic and prophylactic potential as anti-inflammatories,” said Dr. Josep Bassaganya-Riera, a Professor of Immunology, principal investigator of this human clinical trial, and the Director of the NIMML and the Center for Modeling Immunity to Enteric Pathogens." (found here)

"Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis" in PLoS ONE (2012)
"Probiotic bacteria modulate gut microbial diversity and favor local production of CLA in the colon that targets myeloid cell PPAR γ to suppress colitis."

"CLA ameliorates colitis and prevents tumor formation in part through a PPARγ-dependent mechanism...."

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