"Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways " in Biochemical Pharmacology (2009)
"The aim of the present work was to evaluate the anti-inflammatory potential
of 2-styrylchromones (2-SC), a chemical family of oxygen heterocyclic compounds,
vinylogues of flavones (2-phenylchromones), by studying their COX-1 and COX-2
inhibitory capacity as well as their effects on the LTB4 [leukotrene B4] production
by stimulated human polymorphonuclear leukocytes (PMNL). [granulocytes].
Some of the tested 2-SC were able to inhibit both COX-1 activity and
LTB4 production which makes them dual inhibitors of the COX and 5-LOX
pathways. The most effective compounds in this study were those having
structural moieties with proved antioxidant activity (3′,4′-catechol and
4′-phenol substituted B-rings).
This type of compounds may exhibit anti-inflammatory activity with a wider
spectrum than that of classical non-steroidal anti-inflammatory drugs (NSAIDs)
by inhibiting 5-LOX product-mediated inflammatory reactions, towards which
NSAIDs are ineffective."
"Biological activities of 2-styrylchromones" in Mini Rev Med Chem (2010)
"2-Styrylchromones (2-SC) are chromone derivatives characterized by the attachment of a styryl group to the 2-position of the chromone structure. The 2-styrylchromone structure has been demonstrated to bear important biological activities such as antiallergic, antitumor, affinity and selectivity for A(3) adenosine receptors, antiviral, antioxidant and anti-inflammatory. The aim of the present paper was to review the available information on this field."
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