22.6.11

Do lectins worsen Crohn's symptoms?

Lectin from Wikipedia
"Digestion and immune distress ... Foods with high concentrations of lectins, such as beans, cereal grains, seeds, and nuts, may be harmful if consumed in excess in uncooked or improperly cooked form. Adverse effects may include nutritional deficiencies, and immune (allergic) reactions. Possibly, most effects of lectins are due to gastrointestinal distress through interaction of the lectins with the gut epithelial cells. A recent in vitro study has suggested that the mechanism of lectin damage may occur by interfering with the repair of already-damaged epithelial cells."

Lectin Labs Ltd. "Lectins, which are present in almost every organism, are proteins which specifically bind or crosslink carbohydrates on cell surfaces. Through painstaking research, Lectin Labs has identified the precise lectins that have the ability to bind with these carbohydrate receptors that occur on many types of pathogens (bacteria and viral agents that cause disease). Lectin Labs has chosen to develop only lectins from plants, many of which are commonly found in our diet. By using the 'right' lectin, the Company has developed lectin formulations, which are able to interfere with or destroy the development of the disease-causing process, even in cases where antibiotics are ineffective."

The Lowdown on Lectins at Mark's Daily Apple, Primal Living in the Modern World

"Roles of galectins in chronic inflammatory microenvironments" in Future Rheumetology (2006) "Lectins are multifunctional carbohydrate-binding proteins that can recognize various carbohydrates on cell surfaces and extracellular matrix, and are involved in several biological processes. Galectins, a family of animal lectins with affinity for β-galactoside-containing oligosaccharides, are expressed by several cells of the immune system and tissue-resident stromal cells. Increasingly, experimental evidence indicates that galectins might play critical regulatory roles in cancer, fibrosis and chronic inflammatory disorders, such as rheumatoid arthritis. In this review, we summarize recent developments in our understanding of the galectins’ roles within particular cells, and in the broader context of the inflammatory or tumor microenvironments. This body of knowledge, documenting the coming-of-age of galectins as potential immunosuppressive agents or targets for anti-inflammatory drugs, represents a sound basis to further explore their immunoregulatory properties in the development of novel therapies for autoimmune diseases and chronic inflammation."

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