2.10.12

Do rosehips improve Crohn's?

Rose hips from Wikipedia

"Rosehips 'could help tackle inflammatory diseases" in Daily Mail
"In another preliminary study in Denmark involving about 26 patients, LitoZin was found to alleviate the symptoms of Crohn's disease, an inflammatory bowel disorder"

"Fatty Acid Composition of the Monogalactosyldiacylglyerol Fraction Obtained from Rosa sp. and Litozin" in Chemistry of Natural Compounds (2012)
"Rosa canina and Rosa rugosa are common shrubs of the genus Rosa, widely distributed all over Europe. Rose hip or pseudofruit (Rosae fructus) is reported to contain ascorbic acid, organic acids, and minerals. Phytochemical analysis has also revealed the presence of carotenoids, flavonoids, and phenolic acids in rose hips. Rose seeds are rich in lipids. In traditional medicine rose hips are used as a tonic agent in the treatment of exhaustion, infections, and flu. Latest investigations indicated anti-inflammatory, antioxidant, antidiabetic, antimutagenic, and antimicrobial activity in rose hips."

"The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: A prospective cohort study" in Phytomedicine (2011)
"10.5 g Litozin® in 28 days had neither effect on clinical symptoms or laboratory measurements in patients with RA or healthy controls. This is in contrast to previous intervention studies with rose hip powder that found a reduction in the concentration of CRP. The results of the present study indicate that a daily amount of approximately 10 g rose hip powder for one month has no anti-inflammatory and/or antioxidant effect."

"The present study suggests some benefit of patients with RA treated with the present rose hip powder as indicated in the HAQ-DI and the HAQ Patient Global Scale. The secondary outcomes DAS-28, Physician’s Global Scale and QoL assessments RAQoL scores and SF-12 physical support these findings, and no change in the consumption of analgesics, NSAID’s, steroids and DMARD’s were observed in any of the two groups during the six month treatment period. ...The present trial was small and was not to well powered. And thus, though promising, the values should be taken with precaution. Therefore, studies with higher sample size and adequate power for multivariate analysis are warranted. Future research should also include dose-finding studies and testing of different rose hip extractions."

"A systematic review on the Rosa canina effect and efficacy profiles" in Phytotherapy Research (2008)"There is also a rationale behind the use of LitozinR as part of a hypocaloric diet based on the rose hip probiotic, stool regulating and smooth muscle-relaxing actions...."

"A one-year survey on the use of a powder from Rosa canina lito in acute exacerbations of chronic pain" in Phytotherapy Research (2008)
"The rose hip and seed powder, LitozinR, seems to deserve further, more definitive studies as a possible option in long-term management of NSLBP with or without osteoarthritic pain."

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