vitamin B6 from the world's healthiest foods
"Researchers are not yet clear on the mechanisms involved yet, but repeated studies show that vitamin B6 is required to minimize risk of unwanted inflammation in the body. It'xcs not only the case that ample intake of vitamin B6 is associated with decreased risk of excessive inflammation; it's also the fact that individuals with chronic, excessive inflammation need increased amounts of vitamin B6 in their diet."
Tuna is the best source of vitamin B6 overall with cod and halibut offering substantially less. Best meat sources are beef and chicken, turkey, and venison. Vegetable sources include potatoes (which are not recommended for a Crohn's diet, spinach, summer squash, turnip greens, and shiitake mushrooms. The best seed source is sunflower seeds. From the world's healthiest foods
"Homocysteinemia and B vitamin status among adult patients with inflammatory bowel disease: A one-year prospective follow-up study" in Inflammatory Bowel Diseases (2011)
"30% of patients have vitamin B6 deficiency but vitamin B6 is not associated with elevated homocysteine."
"The Impact of Vitamin B6 Supplementation on Experimental Colitis and ColonicMucosal DNA Content in Female Rats Fed High Sucrose Diet" in Australian Journal of Basic and Applied Sciences (2011)
"Vitamin B6 (pyridoxine) plays several roles in the etiology and pathogenesis of chronic inflammation and
inflammatory diseases. It is water-soluble and preferentially absorbed in an acidic medium in the proximal
small intestine via simple diffusion. The vitamin role in inflammation can be observed on a number of
metabolic levels and in various pathologies (Zhang et al., 2006).
Vitamin B6 is believed to be protective against the DNA damage that can lead to cancers and is vital in
DNA synthesis and repair."
are mainly related to the intake of macronutrients, energy and fiber and micronutrients, including ... pyridoxine..."
inflammatory diseases. It is water-soluble and preferentially absorbed in an acidic medium in the proximal
small intestine via simple diffusion. The vitamin role in inflammation can be observed on a number of
metabolic levels and in various pathologies (Zhang et al., 2006).
Vitamin B6 occurs in three forms: pyridoxal, pyridoxine, and pyridoxamine. It is part of coenzymes PLP (pyridoxal phosphate) and PMP (pyridoxamine phosphate) used in amino acid and fatty acid metabolism. It helps to convert tryptophan to niacin and to serotonin, and helps to make red blood cells. It also acts as a co-factor and antioxidant (Chen and Xiong, 2005).Recent studies are unveiling a new role of vitamin B6 as a chemopreventive agent. High levels of vitamin B6 have been reported to suppress growth of animal or human cancer cell in vitro (Valco et al., 2006).
Vitamin B6 seems to be associated with some defense mechanisms especially against lipid peroxidation in tissues, this process occurs when animals are totally lacked in vitamin B6 in the diet (Bordoni et al., 2006). Marginal vitamin B6 contents increased lipid peroxidation and considerably stimulated the activity of glutathione dependent enzymes. On the other hand, increased plasma and tissue lipid peroxidation has been reported in rats receiving a vitamin B6 deficient diet (Kayali and Tarhan, 2006).
Komatsu et al., 2001) postulated that, colorectal cancer risk might be reduced by moderate levels of dietary vitamin B6 daily consumed by humans. Thus, it has been considered that, overdoses of vitamin B6 may have potential use in antineoplastic therapy. A positive association between colon disease and the intake of dietary sources has been found in some human studies although evidence is still insuffient (Lindecrona et al., 2003).
Vitamin B6 seems to be associated with some defense mechanisms especially against lipid peroxidation in tissues, this process occurs when animals are totally lacked in vitamin B6 in the diet (Bordoni et al., 2006). Marginal vitamin B6 contents increased lipid peroxidation and considerably stimulated the activity of glutathione dependent enzymes. On the other hand, increased plasma and tissue lipid peroxidation has been reported in rats receiving a vitamin B6 deficient diet (Kayali and Tarhan, 2006).
Komatsu et al., 2001) postulated that, colorectal cancer risk might be reduced by moderate levels of dietary vitamin B6 daily consumed by humans. Thus, it has been considered that, overdoses of vitamin B6 may have potential use in antineoplastic therapy. A positive association between colon disease and the intake of dietary sources has been found in some human studies although evidence is still insuffient (Lindecrona et al., 2003).
...
The concurrent administration of vitamin B6 exhibited an intestinal anti-inflammatory effect, as evidenced
by a significant improvement of all biochemical parameters of colonic inflammation assayed in comparison
with both non-treated colitic rats and sucrose supplemented rats. ... Thus, higher intake of vitamin B6 leads to higher blood levels of its active form, PLP [Pyridoxal-phosphate (PLP, pyridoxal-5'-phosphate, P5P], which is in turn associated with lower levels of inflammatory molecule (Matxain, 2006).
The concurrent administration of vitamin B6 exhibited an intestinal anti-inflammatory effect, as evidenced
by a significant improvement of all biochemical parameters of colonic inflammation assayed in comparison
with both non-treated colitic rats and sucrose supplemented rats. ... Thus, higher intake of vitamin B6 leads to higher blood levels of its active form, PLP [Pyridoxal-phosphate (PLP, pyridoxal-5'-phosphate, P5P], which is in turn associated with lower levels of inflammatory molecule (Matxain, 2006).
...
Conclusion:Vitamin B6 is believed to be protective against the DNA damage that can lead to cancers and is vital in
DNA synthesis and repair."
"Food intake in patients with Inflammatory Bowel Disease" in ABCD Arq Bras Cir Dig (2011) [full article]
"There was deficiency in food intake in both CD and UC in active and in remission. These deficienciesare mainly related to the intake of macronutrients, energy and fiber and micronutrients, including ... pyridoxine..."
"Vitamin B-6 Intake Is Inversely Related to, and the Requirement Is Affected by, Inflammation Status" in J Nutr (2010)
" In conclusion, higher vitamin B-6 intakes were linked to protection against inflammation and the vitamin B-6 intake associated with maximum protection against vitamin B-6 inadequacy was increased in the presence compared to absence of inflammation."
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