Phosphatidylcholine on Wikipedia
"... a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources such as egg yolk or soy beans from which they are mechanically extracted or chemically extracted using hexane. They are also a member of the lecithin group of yellow-brownish fatty substances occurring in animal and plant tissues."
Phosphatidylcholine.org
Phosphatidylcholine Information and Its Role in Healthy Aging
Supplements
"Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis" in Gut (2005) [full article]
" Phospholipids are one of the components of mucus, consisting of up to 90% phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). They are found as a continuous layer at the luminal and mucosal cell side of the mucus gel and within the mucus as liposome-like aggregates. PC is largely responsible for establishing a protective hydrophobic surface and therefore plays a key role in mucosal defence. A defective PC layer may contribute to the development of inflammation and ulceration, as previously shown in humans with human immunodeficiency virus and Helicobacter pylori infection. In these conditions the pathogenesis involves impairment of phospholipid barrier function as a result of high phospholipase activity. It has been reported that PC, when topically applied to the colon, protects laboratory animals against colitis induced by acetic or trinitrobenzenesulphonic acid. In addition, PC and other selected lipids have been shown to inhibit proinflammatory signalling in a phagosome model system derived from macrophages. Recent analysis of rectoscopically acquired mucus aliquots revealed a significant decrease in PC and LPC content in patients with UC compared with healthy controls or patients with Crohn’s disease. ...
The study medication was provided by Allphamed Pharbil Arzneimittel GmbH (Göttingen, Germany). The PC rich phospholipid mixture (Sterpur P-30 Granulat; Stern-Lecithin and Soja GmbH, Hamburg, Germany) contained 30% PC, 21% phosphatidylethanolamine, and 8% phosphatidylinositol."
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